Preparation and in vivo evaluation of glyco-gold nanoparticles carrying synthetic mycobacterial hexaarabinofuranoside

• Gennady L. Burygin,
• Polina I. Abronina,
• Nikita M. Podvalnyy,
• Sergey A. Staroverov,
• Leonid O. Kononov and
• Lev A. Dykman

Beilstein J. Nanotechnol. 2020, 11, 480–493, doi:10.3762/bjnano.11.39

• suggest that glyco-GNPs are promising agents for the generation of anti-mycobacterial antibodies. Keywords: conjugation of glycosides; gold nanoparticles; lipoarabinomannan; Mycobacterium; spacer aglycon; Introduction A number of bacterial glycans [1][2] are specific markers for the detection and the

• thermodynamic stability with respect to the desorption of capping ligands and subsequent particle aggregation [68]. The nature and the length of the spacer aglycon are known to affect the presentation of carbohydrate ligands [84][85][86][87][88][89][90]. This, in turn, determines the molecular recognition of

• glycosides 1 and 2 (Ara6-GNPs 3 and 4, respectively) allowed us to determine the differences in ability of Ara6 glycosides 1 and 2 to stabilize the GNPs at different pH values (Figure 3). The highest stabilizing ability was demonstrated by Ara6 glycoside 1 with 2-aminoethyl spacer aglycon while Ara6